First Biotech Firm Enters Downtown San Diego with 23,136 SQFT Lease

CBRE, HG Fenton, Mainstay Medical, San Diego, 2171 India Street, Little Italy,
Courtesy of CBRE.

San Diego –– CBRE has announced that Mainstay Medical, a Dublin,  Ireland-based medical device company, has signed a 23,136 square-foot lease in the Little  Italy neighborhood of Downtown San Diego for its new U.S. corporate headquarters. Mainstay  Medical will become the first life science firm to relocate to Downtown San Diego. 

Evan Knudson and Michael Peterson of CBRE represented the landlord, local real estate firm  H.G. Fenton Company, in the transaction. 

Mainstay Medical will occupy space at 2171 India Street, part of a project featuring a mix of  office, retail and dining tenants. The property sits just west of I-5 and is within walking distance  of dozens of San Diego’s most popular dining, retail and entertainment destinations. Mainstay  Medical plans to perform both office and medical device operations out of this location. 

“This is a landmark deal for Downtown San Diego that builds on the momentum of recent  large-scale investments in the life science space by IQHQ and Phase 3,” said Mr. Knudson. “Mainstay Medical’s new US headquarters in Little Italy was chosen for its European and urban  feel, walkable amenities and close proximity to the airport and mass transit.” 

Mr. Peterson added, “While San Diego County has long been known for the strength of its life  science industry, these firms have never before entered the Downtown San Diego submarket.  Mainstay Medical will be the first of many life science firms to enjoy all of the amenities that Downtown and Little Italy have to offer.” 

He added, “H.G. Fenton understood Mainstay’s vision and capitalized on the opportunity of  this burgeoning product type. This is a fantastic outcome from a market-leading ownership  group that has cultivated the growth of Little Italy. From the development of Piazza della  Famiglia to this first-to-market life science use, H.G. Fenton continues to add value to the  vibrant Little Italy neighborhood.”

About CBRE Group, Inc. 

CBRE Group, Inc. (NYSE: CBRE), a Fortune 500 and S&P 500 company headquartered in Dallas, is the  world’s largest commercial real estate services and investment firm (based on 2020 revenue). The  company has more than 100,000 employees serving clients in more than 100 countries. CBRE serves  a diverse range of clients with an integrated suite of services, including facilities, transaction and project  management; property management; investment management; appraisal and valuation; property  leasing; strategic consulting; property sales; mortgage services and development services. Please visit  our website at 

About H.G. Fenton Company 

H.G. Fenton Company, a family-owned San Diego real estate company, has proudly entered its second  century of service providing quality working and living experiences through responsible development  and management practices. H.G. Fenton Company creates lifestyle opportunities where employees  flourish, residents live well, and businesses succeed for over 1,100 businesses, and across 17 apartment  communities totaling over 3,500 homes in San Diego County. Learn more at